It marks the first time that the pair has crossed paths in Sheffield since their memorable 2014 showdown in the final.
Both players will have the opportunity to reach a maiden world final when they face off against each other in the last four.
Below is the 2020 Betfred World Snooker Championship draw at the Crucible Theatre in Sheffield
The 2019 world champion joins a long list of former first-time champions to fail in defending their crown.
Below is the World Snooker Championship schedule for day 12 at the Crucible Theatre in Sheffield.
A total of six out of the top eight seeds have made it through to this stage for the first time since 2015.
Snooker, like any sport, has had its fair share of rivalries down through the years.
The world number one was pushed all the way as the defense of this title continues.
The three-time champion edged Stuart Bingham in a tense battle of the former Crucible winners.